Dynamics, Binding and Function of Intrinsically Disordered Proteins (Hardcover)

Dynamics, Binding and Function of Intrinsically Disordered Proteins By Rudyard Ramsey (Editor) Cover Image

Dynamics, Binding and Function of Intrinsically Disordered Proteins (Hardcover)

By Rudyard Ramsey (Editor)

$154.00


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Intrinsically disordered proteins (IDPs) are a class of proteins that do not fold into a specific three-dimensional structure, which is a characteristic of proteins. The structural flexibility of IDPs range from fully structured to partially structured, which enables them to complement ordered proteins in order to perform functions that cannot be performed by rigid structures. Several factors such as pH and temperature can affect the shape and level of disorder in proteins. IDPs have been associated with various diseases such as cancer and cardiovascular diseases. The accumulation of an IDP called α-synuclein plays a pathophysiological role in Parkinson's disease (PD). The structural flexibility of the unstructured α-synuclein protein and associated disease mechanisms is affected by several factors such as genetics, oxidative stress, nitrative stress, and mitochondrial impairment. The book aims to shed light on some of the unexplored aspects of intrinsically disordered proteins and the recent researches on them. It will serve as a valuable source of reference for the graduate and postgraduate students.
Product Details ISBN: 9781646465712
ISBN-10: 1646465717
Publisher: Foster Academics
Publication Date: September 19th, 2023
Pages: 254
Language: English