Computational Systems Pharmacology and Toxicology (Issues in Toxicology #31) (Hardcover)
This book presents systems pharmacology and toxicology approaches to computational toxicology, linking chemical exposures to genes, diseases and complex biological pathways. It discusses new methods to study chemical and biological target elucidation and computational models. These computational tools hold tremendous promise for advancing applied and basic science, streamlining drug efficacy and safety testing, reducing the use of animals in testing, and increasing the efficiency and effectiveness of risk assessment for environmental chemicals. This timely and modern book will be of interest to risk assessors as well as toxicologists and pharmacologists. The case study section will make it particularly useful for academic course work at graduate and undergraduate level.
Dr Dale E. Johnson is currently an Adjunct Professor in Molecular Toxicology at UC Berkeley and an Adjunct Professor in Environmental Health Sciences at the University of Michigan. He teaches computational toxicology, drug discovery & development, and lectures in pharmacogenomics. He is also President and CEO of Emiliem, Inc. and CEO of Elara Bioscience LLC, a software company. He also consults for biopharmaceutical companies and investment firms. Dr Johnson has over 30 years' experience as a research and development scientist, manager, executive, and entrepreneur in the biopharmaceutical field working in large pharmaceutical and biotech companies and several start-ups. Prior to Emiliem, he served as VP Drug Assessment & Development and VP Preclinical Development at Chiron Corporation and previously worked at Hoechst-Roussel Pharmaceuticals, International Research and Development Corp., Medical Research Division of American Cyanamid, Eos Biotechnology and Ddplatform. Dr Rudy J. Richardson is currently the Dow Professor of Toxicology at the University of Michigan. He also holds a joint appointment in the Neurology Department. Sabbatical leaves at Warner-Lambert/Parke-Davis (now Pfizer) in Ann Arbor and the University of Padua in Italy. Dr Richardson has served several times as the Director of the Toxicology Program, and currently he serves as Graduate Chair of the EHS Department. His research interests include computational toxicology, biomarkers and biosensors of exposure and disease, mechanisms of neurodegenerative disease, chemistry and toxicology of organophosphorus and organic nitro compounds, and interactions of toxicants with target macromolecules.